NRG Fusion Market to Grow at a CAGR of 15% Due to Expected First Launch of Merus' Zenocutuzumab and Increased Adoption of NRG1 Fusion Biomarker Testing During the Study Period (2020-2034) | DelveInsight
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Key Takeaways from the NRG Fusion Market Report
Discover which therapies are expected to grab the NRG fusion market share @ NRG Fusion Market Report
NRG Fusion Market Dynamics
NRG fusions have been found in more than 10 types of solid tumors, suggesting they are a promising target for a broad, tumor-agnostic therapeutic approach. Increasing awareness and research in this area make it an appealing opportunity for major industry players. Various ERBB3 inhibitors with encouraging preclinical results are progressing through different stages of clinical trials, including combinations with ERBB2-targeting drugs for ERBB2-positive breast and gastric cancers.
Currently, there are no approved targeted therapies specifically for NRG fusions. For advanced tumors with NRG1 fusions, the standard treatment remains chemotherapy, immunotherapy, or novel anti–PD–1 or anti–PD-L1 agents, though these options often yield suboptimal responses in these patients. NRG fusions are rare but significant oncogenic events seen across several tumor types, including non-small cell lung cancer, breast cancer, colon cancer, pancreatic cancer, and cholangiocarcinoma.
Various strategies to target the HER3 pathway, such as monoclonal antibodies, bispecific T-cell engagers, and antibody-drug conjugates, are under investigation. Early results indicate poor outcomes for patients with NRG1 fusions, highlighting the need for new therapeutic options. Among emerging treatments, Merus's zenocutuzumab is at the forefront, with the FDA having accepted a BLA for this drug in May 2024 to treat non-small cell lung cancer and pancreatic cancer. The FDA is expected to decide by December 2024.
NRG Fusion Treatment Market
Currently, there are no approved targeted therapies specifically for NRG fusions. For advanced tumors with NRG fusions, standard treatments involve chemotherapy and/or immunotherapy or newer anti–PD–1 or anti–PD-L1 agents. However, these therapies often yield suboptimal responses for patients with NRG1 fusions. While developing new drugs for rare conditions is challenging, repurposing existing drugs approved for other uses is a practical approach. In the case of NRG1 fusion-driven tumors, existing ErbB-targeted therapies show promise. Since NRG1 proteins are ligands for ErbB receptors, treatments like the monoclonal antibody zenocutuzumab and small molecules such as afatinib are particularly noteworthy.
Learn more about the FDA-approved NRG fusion therapies @ NRG Fusion Drugs
Key Emerging NRG Fusion and Companies
Several key players, including Elevation Oncology, Merus, Hummingbird Bioscience, Salubris Biotherapeutics, and others, are involved in developing drugs for NRG fusion for various indications.
Seribantumab (MM-121) is a fully human monoclonal antibody developed by Elevation Oncology. It targets and inhibits HER3 signaling, which supports tumors with NRG1 gene fusions. By binding to HER3, Seribantumab prevents the NRG1 fusion protein from over-activating it. The antibody is being pursued as a targeted therapy for tumors driven by NRG1 fusions. In May 2022, Seribantumab received fast-track designation from the FDA for the treatment of advanced solid tumors with NRG1 gene fusions. Elevation Oncology is now looking for a partnership to secure further investment for the drug.
Zenocutuzumab (MCLA-128), an experimental drug developed by Merus, targets and inhibits the growth factor NRG1, which can become excessive due to NRG1 fusions and interfere with HER3 binding. This bispecific antibody can recognize and bind to both HER2 and HER3. Its mechanism involves first attaching to HER2, which subsequently prevents HER3 from interacting with NRG1. Zenocutuzumab is currently undergoing Phase II clinical trials for treating solid tumors with NRG1 fusions. The FDA has granted priority review for its Biologics License Application (BLA) for use in treating NRG1 fusion-positive NSCLC and pancreatic cancer.
The anticipated launch of these emerging therapies are poised to transform the NRG fusion market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the NRG fusion market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
To know more about NRG fusion therapies clinical trials, visit @ NRG Fusion Treatment Drugs
NRG Fusion Overview
Neuregulins (NRG) are a group of epidermal growth factor (EGF) ligands commonly found in solid tumors. There are four genes—NRG-1, NRG-2, NRG-3, and NRG-4—that produce over 32 different NRG isoforms. NRGs function by interacting with the ErbB/HER family of receptor tyrosine kinases. In mammals, four ErbB/HER receptors have been identified: ErbB1/HER1/EGFR, ErbB2/HER2/neu, ErbB3/HER3, and ErbB4/HER4. These receptors and their ligands are well-studied in cancer research due to their role in oncogenic transformation and are targeted by various therapies, including monoclonal antibodies like trastuzumab and pertuzumab for HER2, cetuximab for EGFR, and tyrosine kinase inhibitors such as lapatinib for both EGFR and HER2.
NRG Fusion Epidemiology Segmentation
Among the 7MM, the US accounted for the highest incident cases of NRG Fusion in 2023. The NRG fusion market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:
Scope of the NRG Fusion Market Report
Discover more about NRG fusion drugs in development @ NRG Fusion Clinical Trials
Table of Contents
Related Reports
Rare NRG1 Fusion Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key rare NRG1 fusion companies, including Elevation Oncology, Merus, Hummingbird Bioscience, Boehringer Ingelheim, AVEO Oncology, CANbridge Pharmaceuticals, Salubris Biotherapeutics, among others.
Rare NRG1 Fusion Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key rare NRG1 fusion companies, including Elevation Oncology, Merus, Hummingbird Bioscience, Boehringer Ingelheim, AVEO Oncology, CANbridge Pharmaceuticals, Salubris Biotherapeutics, among others.
Non-small Cell Lung Cancer Market
Non-small Cell Lung Cancer Market Insights, Epidemiology, and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key NSCLC companies, including EMD Serono, Merck, Cellular Biomedicine Group, Inc., Celgene, CellSight Technologies, Inc., BeyondSpring Pharmaceuticals Inc., J Ints Bio, Forward Pharmaceuticals Co., Ltd., AstraZeneca, Bristol-Myers Squibb, Teligene US, Rain Oncology Inc, ReHeva Biosciences, Inc., Amgen, Novartis, RedCloud Bio, Parexel, Vitrac Therapeutics, LLC, Mythic Therapeutics, Instil Bio, Mirati Therapeutics Inc., Daiichi Sankyo, Inc., AstraZeneca, Precision Biologics, Inc, Promontory Therapeutics Inc., Palobiofarma SL, Regeneron Pharmaceuticals, Revolution Medicines, Inc., Cullinan Oncology, LLC, Iovance Biotherapeutics, Inc., Innate Pharma, among others.
Non-small Cell Lung Cancer Pipeline
Non-small Cell Lung Cancer Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key non-small cell lung cancer companies, including BridgeBio Pharma, Daiichi Sankyo, EMD Serono, Merck, BridgeBio Pharma, Abbvie, Pfizer, Eli Lilly and Company BioNTech SE, Shenzhen TargetRx, Taiho Pharmaceutical, Chong Kun Dang, Bristol Myers Squibb, Innovent Biologics, Xuanzhu Biopharmaceutical, Bayer, GeneScience Pharmaceuticals, InventisBio, Apollomics, Imugene, Ono Pharmaceutical, Pierre Fabre, Jiangsu Hengrui Medicine Co., Bristol-Myers Squibb, Surface Oncology, Inhibrx, Sinocelltech, Mirati Therapeutics, REVOLUTION Medicines, Yong Shun Technology Development, Iovance Biotherapeutics, Galecto Biotech, among others.
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