A major advance on stroke at Montpellier University Hospital published in the New England Journal of Medicine

Trial of Thrombectomy for Stroke with a Large Infract of Unrestrited Size, published in the New England Journal of Medicine https://www.nejm.org/

Since mechanical thrombectomy, a technique that aims to restore blood flow in stroke patients who experience sudden occlusion of a brain artery, by removing the blockage with device-based technologies, became standard of care in 2015, physicians selected for such intervention only stroke patients who displayed limited amounts of brain damage on brain imaging. This was based on the principle that restoration of blood flow to large areas of irreversibly damaged brain  is not only futile but can also cause additional damage due to an increased risk of bleeding in the brain among other detrimental effects of reperfusion. 

Yet, an international network of stroke centers led by the Montpellier University Hospital investigators has proven the opposite. The multicenter therapeutic trial "LASTE" was conducted in France (26 centers) and Spain (7 centers) for 3 years. The trial aimed to select patients hitherto considered "irrecoverable" in common practice due to unrestrictedly large areas of irreversibly compromised brain presenting with acute stroke due to large vessel occlusion within 7 hours of stroke onset to test the hypothesis that reperfusion of brain tissue considered dead could improve their outcome not only in term of survival but also in terms of functional recovery.

IN EXTREMIS TRIALS LASTE and MOSTE are sponsored by an Industrial unrestricted grant co-founded by 5 industrial partners (BALT, CERENOVUS, MEDTRONIC, MICROVENTION, STRYKER).

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